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Analysis of anti-SARS-CoV-2 IgG antibody titers after mRNA booster vaccination in patients with nonmalignant hematological disorders
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- HAGIHARA Masao
- Department of Hematology, Eiju General Hospital
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- SUGI Tomiyuki
- Department of Pharmacy, Eiju General Hospital
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- HAYASHI Hiroyoshi
- Department of Hematology, Eiju General Hospital
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- NAKASHIMA Shiori
- Department of Hematology, Eiju General Hospital
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- OHARA Shin
- Department of Hematology, Eiju General Hospital
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- IMAI Yui
- Department of Hematology, Eiju General Hospital
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- NAKANO Hirofumi
- Department of Hematology, Eiju General Hospital
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- UCHIDA Tomoyuki
- Department of Hematology, Eiju General Hospital
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- INOUE Morihiro
- Department of Hematology, Eiju General Hospital
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- MITAMURA Keiko
- Department of Preventive Medicine, Eiju General Hospital
Bibliographic Information
- Other Title
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- 非悪性血液疾患におけるコロナブースターワクチン接種後のSARS-CoV-2 IgG抗体価の解析
- ヒアクセイ ケツエキ シッカン ニ オケル コロナブースターワクチン セッシュ ゴ ノ SARS-CoV-2 IgG コウタイカ ノ カイセキ
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Description
<p>In our facility, anti-SARS-CoV-2 mRNA vaccines were given to 21 patients, including 8 with aplastic anemia (AA), 3 with pure red cell aplasia (PRCA), and 10 with immune thrombocytopenic purpura (ITP), and IgG antibody titers were assessed one month after vaccinations. After receiving both a second vaccine and a booster shot, all patients with AA/PRCA treated with cyclosporine A aside from one, had IgG titers that were lower than the median levels of healthy controls. Even if prednisolone (PSL) doses did not go over 10 mg/day, ITP patients receiving PSL therapy were unable to achieve adequate levels of IgG after booster immunizations.</p>
Journal
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- Rinsho Ketsueki
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Rinsho Ketsueki 64 (2), 133-136, 2023
The Japanese Society of Hematology