Analysis of anti-SARS-CoV-2 IgG antibody titers after mRNA booster vaccination in patients with nonmalignant hematological disorders

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  • 非悪性血液疾患におけるコロナブースターワクチン接種後のSARS-CoV-2 IgG抗体価の解析
  • ヒアクセイ ケツエキ シッカン ニ オケル コロナブースターワクチン セッシュ ゴ ノ SARS-CoV-2 IgG コウタイカ ノ カイセキ

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Abstract

<p>In our facility, anti-SARS-CoV-2 mRNA vaccines were given to 21 patients, including 8 with aplastic anemia (AA), 3 with pure red cell aplasia (PRCA), and 10 with immune thrombocytopenic purpura (ITP), and IgG antibody titers were assessed one month after vaccinations. After receiving both a second vaccine and a booster shot, all patients with AA/PRCA treated with cyclosporine A aside from one, had IgG titers that were lower than the median levels of healthy controls. Even if prednisolone (PSL) doses did not go over 10 mg/day, ITP patients receiving PSL therapy were unable to achieve adequate levels of IgG after booster immunizations.</p>

Journal

  • Rinsho Ketsueki

    Rinsho Ketsueki 64 (2), 133-136, 2023

    The Japanese Society of Hematology

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