Image diagnosis and mapping biopsy to assess the superficial ductal spread of the biliary tract cancer

DOI
  • Okuno Mitsuru
    Department of Gastroenterology, Gifu Municipal Hospital
  • Iwata Keisuke
    Department of Gastroenterology, Gifu Municipal Hospital
  • Mukai Tsuyoshi
    Department of Gastroenterology, Gifu Municipal Hospital Department of Gastroenterological Endoscopy, Kanazawa Medical University
  • Ohashi Yosuke
    Department of Gastroenterology, Gifu Municipal Hospital
  • Iwata Shota
    Department of Gastroenterology, Gifu Municipal Hospital
  • Iwasa Yuhei
    Department of Gastroenterology, Gifu Municipal Hospital
  • Yoshida Kensaku
    Department of Gastroenterology, Gifu Prefecture General Medical Center
  • Maruta Akinori
    Department of Gastroenterology, Gifu Prefecture General Medical Center
  • Uemura Shinya
    First Department of Internal Medicine, Gifu University Hospital
  • Iwashita Takuji
    First Department of Internal Medicine, Gifu University Hospital
  • Tomita Eiichi
    Department of Gastroenterology, Gifu Municipal Hospital
  • Shimizu Masahito
    First Department of Internal Medicine, Gifu University Hospital

Bibliographic Information

Other Title
  • 胆管癌水平方向進展度診断における画像診断とマッピングバイオプシーの有用性

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Abstract

<p>Background: Mapping biopsy (MB) of the bile duct can help evaluate the pathology of biliary cancer's superficial ductal spread (SDS). However, MB can give false positive or false negative results. Therefore, this study aimed to evaluate the effectiveness of MB.</p><p>Method: Thirty-one patients with the perihilar cholangiocarcinoma (PHCC) and 52 with distal bile duct cancer (DBDC) who underwent MDCT, ERC, MB, and surgical resection between 2010 and 2021 were included. The diagnostic ability of image diagnosis (MDCT with ERC) and MB for SDS was evaluated.</p><p>Result: The sensitivity and specificity of PHCC were as follows: intrahepatic bile duct side (image diagnosis/MB: 43%/57% [P = 1.0], and 100%/79% [P < 0.05], respectively), distal bile duct side (100%/100% [P = 1.0], and 100%/79% [P < 0.05], respectively). For DBDC (intrahepatic bile duct side), these values were 22%/56% [P = 0.3], and 100%/70% [P < 0.01], respectively. MB is considered to have high sensitivity but significantly low specificity.</p><p>Conclusion: We consider that the false-positive identification by MB was caused by tumor contamination during the insertion of biopsy forceps. Therefore, it is necessary to take measures to prevent tumor contamination.</p>

Journal

  • Tando

    Tando 37 (1), 45-54, 2023-03-31

    Japan Biliary Association

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