A Case of SAPHO Syndrome with Extensive Subcutaneous Abscesses Successfully Treated with Adalimumab

DOI
  • Hirota Nanako
    Department of Dermatology, Kindai University Faculty of Medicine
  • Kato Maiko
    Department of Dermatology, Kindai University Faculty of Medicine
  • Nakashima Chisa
    Department of Dermatology, Kindai University Faculty of Medicine
  • Yanagihara Shigeto
    Department of Dermatology, Kindai University Faculty of Medicine
  • Oiso Naoki
    Department of Dermatology, Kindai University Faculty of Medicine
  • Morotomi Makiko
    Division of Dermatology, Izumisano Yujinkai Hospital
  • Yamamoto Toshiyuki
    Department of Dermatology, Fukushima Medical University School of Medicine
  • Kawada Akira
    Department of Dermatology, Kindai University Faculty of Medicine
  • Otsuka Atsushi
    Department of Dermatology, Kindai University Faculty of Medicine

Bibliographic Information

Other Title
  • アダリムマブで寛解しえた広範囲皮下膿瘍を伴う SAPHO 症候群の1 例

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Abstract

<p>A 60-year-old woman had suffered from neck, chest and ankle joint pain for the past 10 years. Five years ago, she developed skin lesions on her palms and soles and was diagnosed with palmoplantar pustulosis. She continued to have recurrent episodes of skin inflammation and abscesses of the chest area, which were treated with incisional drainage and antibiotics following remissions and exacerbations. In our hospital, we also observed erythema, sensations of burning,swelling, fistula, and abscesses in the anterior thoracic region, indicating an increased inflammatory response. In addition, CT, MRI images, and bone scintigraphy revealed subcutaneous abscess, and accumulation on the bone, which led to the diagnosis of SAPHO syndrome. Administration of adalimumab for four months achieved marked improvement of skin and bone lesions. We experienced a case in which the patient did not improve with antimicrobial therapy and incisional drainage but improved markedly with adalimumab. Skin Research, 21 : 328-332, 2022 </p>

Journal

  • Hifu no kagaku

    Hifu no kagaku 21 (4), 328-332, 2022

    Meeting of Osaka Dermatological Association/Meeting of Keiji Dermatological Association

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