Clinical Study of Patients with Rash Caused by Carbamazepine

Hirose （Sawano） Shikiko, Noguchi Tomoyasu, Fukuda Ken-ichi

doi:10.11264/jjop.15.31

Patients: For a duration of 5 years from January 2016 to December 2021, we examined 195 patients who visited the Department of Pain Clinic, Suidobashi Hospital, Tokyo Dental College, and were diagnosed with trigeminal neuralgia. Of the 195 patients who were prescribed carbamazepine （CBZ）, we report on the progress and treatment of 5 cases in which rash was observed. <br>Discussion: CBZ is the drug of choice for treatment of trigeminal neuralgia and is also used for diagnosis and differentiation. Pain control is often difficult when alternative drugs are used due to side effects. Thereby, stereotactic radiotherapy, and nerve blocks are indicated. In our department, when CBZ cannot be continued, we administer pregabalin and amitriptyline alone or in combination, and request surgery and stereotactic radiotherapy to other hospitals. Since trigeminal neuralgia requires an increase in the dose of CBZ as the condition worsens, side effects such as liver damage are more likely to occur. The study therefore was able to reconfirm the necessity of conducting regular hematological tests over a long period of time and confirming general conditions such as liver function status and blood image for detection. <br>Conclusion: Although the administration of CBZ does require caution, it is the concluded that CBZ can be used safely as the first-choice drug for the treatment of trigeminal neuralgia.

Clinical Study of Patients with Rash Caused by Carbamazepine

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