A Case of Male Breast Cancer Associated with Neurofibromatosis Type 1

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  • 神経線維腫症1型に合併した男性乳癌の1例
  • シンケイ センイ シュショウ 1ガタ ニ ガッペイ シタ ダンセイ ニュウガン ノ 1レイ

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Abstract

<p>A 78-year-old man presented with a 3-cm right breast tumor, located below the nipple. On physical examination, multiple café au lait spots and thumb's head-sized soft brown masses were observed on the trunk. He was diagnosed with neurofibromatosis type 1 (NF1). Mammary gland ultrasound revealed a 2.9 × 1.6 × 2.3 cm mass. He was diagnosed with invasive ductal breast cancer by needle biopsy. The patient underwent right pectoralis muscle preservation mastectomy + sentinel lymph node biopsy with axillary lymph node dissection. Pathological examination revealed a pT2N1M0 pStage IIB tumor. He was managed postoperatively with oral tamoxifen 20 mg/day. No recurrence was observed. Although NF1 is often associated with malignant tumors, reports of male breast cancer associated with NF1 are rare. We report this case along with a literature review.</p>

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