Giemsa staining proved useful for fine-needle aspiration cytology of an atypical lipomatous tumor arising in the subcutaneous tissue of the left upper neck

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  • 左上頸部の皮下に発生した異型脂肪腫様腫瘍の穿刺吸引細胞診断に Giemsa 染色が有用であった 1 例
  • ―A case report―

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Abstract

<p>Background : Atypical lipomatous tumor/well-differentiated liposarcoma is a tumor of intermediate malignant grade that shows differentiation into adipose cells. Herein, we report a case of an atypical lipomatous tumor arising in the subcutaneous tissue of the left upper neck, focusing on the findings of fine-needle aspiration cytology of the tumor.</p><p>Case : A man in his late 40 s. He was referred to our Department of Otolaryngology for detailed investigation of a swelling in the left upper cervical region. Fine-needle aspiration cytology revealed clusters of cells composed of adipose cells containing enlarged nuclei and atypical pleomorphic stromal cells. These cells included atypical lipoblasts and binucleated cells. In addition, mast cells were found to be in contact with the atypical stromal cells. The cell types atypical lipoblasts could be identified more easily in Giemsa-stained specimens than in Papanicolaou-stained specimens. Immunocytochemistry showed partially positive staining of the nuclei of the atypical cells for murine double minute 2 (MDM2). The histopathological diagnosis of the tumor was also atypical lipomatous tumor.</p><p>Conclusion : These findings suggest the usefulness of Giemsa staining for the diagnosis in fine-needle aspiration cytology of lipomatous tumors.</p>

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