Synthesis of Radioiodine-labeled Nanocarrier Composed of Poly(L-Lactic Acid)-<i>block</i>-Poly(Sarcosine) Amphiphilic Polydepsipeptide and Its Biodistribution in Tumor-bearing and Inflammation Model Mice

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  • Kimura Mitsuharu
    Faculty of Pharmaceutical Sciences, Tohoku Medical and Pharmaceutical University
  • Onishi Ibuki
    Faculty of Pharmaceutical Sciences, Tohoku Medical and Pharmaceutical University
  • Yamamoto Yumi
    Faculty of Pharmaceutical Sciences, Tohoku Medical and Pharmaceutical University
  • Saito Yohei
    Faculty of Pharmaceutical Sciences, Tohoku Medical and Pharmaceutical University
  • Fukuda Hiroshi
    Faculty of Medicine, Tohoku Medical and Pharmaceutical University
  • Makino Akira
    Biomedical Imaging Research Center, University of Fukui
  • Kiyono Yasushi
    Biomedical Imaging Research Center, University of Fukui
  • Saji Hideo
    Graduate School of Pharmaceutical Sciences, Kyoto University
  • Ozeki Eiichi
    Technology Research Laboratory, Shimadzu Corporation
  • Kimura Shunsaku
    Graduate School of Engineering, Kyoto University
  • Yamamoto Fumihiko
    Faculty of Pharmaceutical Sciences, Tohoku Medical and Pharmaceutical University

Bibliographic Information

Other Title
  • Poly(L-lactic acid)-<i>block</i>-poly（sarcosine）両親媒性ポリデプシペプチドからなる放射性ヨウ素標識ナノキャリアの合成と担癌マウス及び炎症モデルマウスにおける生体内分布
  • Synthesis of Radioiodine-labeled Nanocarrier Composed of Poly(L-Lactic Acid)-block-Poly(Sarcosine) Amphiphilic Polydepsipeptide and Its Biodistribution in Tumor-bearing and Inflammation Model Mice

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Description

<p>We have developed amphiphilic polydepsipeptide micelle “lactosome” as a novel nanocarrier with tumor accumulation properties for cancer imaging probes. In this study, radioiodine-labeled lactosomes were synthesized and evaluated to develop diagnostic radiotracers for in vivo imaging utilizing single photon emission computed tomography (SPECT). The 125I-labeled lactosome was obtained in sufficient yields for biodistribution studies. Radioactivity in the blood circulation was maintained at a high level between 2–48 h post-injection of 125I-labeled lactosome into BALB/c mice. Radioactivity uptake by the Colon-26 tumor implanted in the femur gradually increased. The uptake ratio of subcutaneous tumor/muscle increased to 16.7 at 48 h post-injection. Additionally, tumor SPECT imaging of 123I-labeled lactosome in mice was achieved. Radioactivity uptake of turpentine-induced inflamed tissue reached a maximum at 24 h and then decreased at 48 h post-injection. The mean uptake ratio of inflammatory tissue/muscle increased to 14.4 at 24 h. In conclusion, radioiodine-labeled lactosomes as nanocarriers may serve as potential candidates in facile and generic tumor or inflammation imaging techniques.</p>

Journal

  • RADIOISOTOPES

    RADIOISOTOPES 72 (2), 149-161, 2023-07-15

    Japan Radioisotope Association

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