A reflection on two decades of metabolomic innovations in capillary electrophoresis-mass spectrometry at the Institute for Advanced Biosciences, Keio University

DOI IR

Bibliographic Information

Other Title
  • Metaboromikusu no gijutsu kakushin ni taisuru Keiō gijuku daigaku sentan seimei kagaku kenkyūjo no 20nen ni wataru kōken

Search this article

Description

type:text

The Institute for Advanced Biosciences (IAB) at Keio University was first established in April 2001 to become a leading international metabolomics center for advancing integrated systems biology research. Unlike other metabolomic centers worldwide, IAB strategically focused on developing capillary electrophoresis-mass spectrometry (CE-MS) technology as their central instrumental platform for comprehensive analysis of polar/ionic metabolites in conjunction with bioinformatic tools for biomarker discovery and biochemical interpretation. In addition to hosting two International Metabolomics Society conferences, training young scientists and founding successful spin-off companies, IAB has contributed to high impact metabolomic studies as applied to clinical medicine, functional genomics and multi-omic studies, cancer diagnostic testing, agriculture and food science, as well as epidemiology and population health. IAB has also fostered metabolomic partnerships with the local community, clinicians and industry as reflected by their involvement in a prospective study of community-dwelling residents from Tsuruoka City and assessment of the quality of foods produced from the Shonai area. IAB has also spearheaded numerous CE-MS based metabolomic research collaborations elsewhere across Japan and worldwide. This short review will strive to highlight key milestones spanning over 20 years of research innovations in CE-MS metabolomics technology brought forth under the leadership of Dr. Masaru Tomita.

特集 SFCバイオの軌跡 第1章 先端生命科学 招待論文 : 総説・レビュー論文

Journal

Keywords

Details 詳細情報について

Report a problem

Back to top