Transdermal Absorption Enhancement of Cosmetic Ingredients into the Stratum Corneum by Multi Spike Moist Pulse

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  • 複合浸透波形による美容成分の角層への浸透促進

Abstract

<p>Several ways have been reported to enhance the penetration of cosmetic ingredients into the stratum corneum through electrical waveforms. We recently developed the complexed penetration waveform, Multi Spike Moist Pulse (MSMP) which includes electroporation and radiofrequency factors. Our experimental results show that MSMP is the most effective electrical waveform pattern in two different (positive/+ or negative/-) chemical structures. (1) We confirmed that iontophoresis (+/-)showed a higher tendency in penetration than the control, but no significant difference was found between these waveforms and the control. And radiofrequency showed a higher penetration than the control in a positive/+ structure. (2) We showed that MSMP promotes a higher transdermal absorption of nicotinamide than the rectangular wave under the same energy intensity. Therefore, it is concluded that MSMP can promotes the higher absorption of cosmetic ingredients in an effective way.</p>

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