Construction of human iPS cells-derived blood-brain barrier model and evaluation of transporter function

DOI Web Site 23 References
  • Kurosawa Toshiki
    Laboratory of Drug Disposition and Pharmacokinetics, Faculty of Pharma-Sciences, Teikyo University
  • Sako Daiki
    Laboratory of Drug Disposition and Pharmacokinetics, Faculty of Pharma-Sciences, Teikyo University
  • Kubo Yoshiyuki
    Laboratory of Drug Disposition and Pharmacokinetics, Faculty of Pharma-Sciences, Teikyo University
  • Deguchi Yoshiharu
    Laboratory of Drug Disposition and Pharmacokinetics, Faculty of Pharma-Sciences, Teikyo University

Bibliographic Information

Other Title
  • ヒトiPS細胞由来血液脳関門モデルの構築とトランスポーター機能評価

Abstract

The blood-brain barrier （BBB） regulates the transport of substances between the brain and blood by forming tight junctions of brain microvascular endothelial cells. It is important for the development of drug delivery technology into the brain and effective CNS drugs to construct in vitro BBB models that enable the evaluation of transport into the human brain. However, evaluations in experimental animals, or existing models of human cells, have revealed their problems with species differences and tight junction formation. Recently, a method has been developed to differentiate brain microvascular endothelial cells from human iPS cells, which is expected to be a new human BBB model. In order to apply it to drug discovery and disease research, it is necessary to evaluate the variety of functional proteins in the BBB as well as the ability to form tight junctions in this human BBB model. In this review, we describe our research regarding the function of transporters in human iPS cells-derived BBB model and outline the usefulness of this model, including the differentiation methods and applications in disease research.

Journal

  • Drug Delivery System

    Drug Delivery System 38 (2), 117-124, 2023-03-25

    THE JAPAN SOCIETY OF DRUG DELIVERY SYSTEM

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