Brain-targeted drug delivery system based on microbubbles and ultrasound technology
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- Omata Daiki
- Laboratory of drug and gene delivery research, Faculty of Pharma-Science, Teikyo University
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- Munakata Lisa
- Laboratory of drug and gene delivery research, Faculty of Pharma-Science, Teikyo University
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- Maruyama Kazuo
- Laboratory of Theranostics, Faculty of Pharma-Science, Teikyo University Advanced Comprehensive Research Organization, Teikyo University
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- Suzuk Ryo
- Laboratory of drug and gene delivery research, Faculty of Pharma-Science, Teikyo University Advanced Comprehensive Research Organization, Teikyo University
Bibliographic Information
- Other Title
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- 超音波とマイクロバブルを用いた脳標的薬物送達の現状と展望
- チョウオンパ ト マイクロバブル オ モチイタ ノウ ヒョウテキ ヤクブツ ソウタツ ノ ゲンジョウ ト テンボウ
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Abstract
Blood-brain barrier restricts the transport of molecules between blood and brain parenchyma. Although blood-brain barrier is required to protect the brain from an invasion of harmful molecules, it is also an obstacle in the drug delivery to treat the disease in the brain. Therefore, several drug delivery systems are tried to be developed for efficient drug delivery to the brain. Recently, it has taken much attention that the combination of ultrasound and microbubbles, which is an ultrasound contrast agent, to increase the permeability of blood brain barrier. Ultrasound exposure induces the compression and expansion of microbubbles, and the mechanical behavior of microbubbles affects endothelial cells in the brain, resulting in enhancing the permeability of blood-brain barrier. It has been reported that the optimized ultrasound condition and characteristics of microbubble achieved less-invasive and efficient drug delivery to the brain. In this review, we introduce our study for brain targeted drug delivery using the combination of ultrasound and microbubbles and describe the current studies and prospects.
Journal
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- Drug Delivery System
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Drug Delivery System 38 (2), 155-163, 2023-03-25
THE JAPAN SOCIETY OF DRUG DELIVERY SYSTEM
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Keywords
Details 詳細情報について
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- CRID
- 1390859525239753728
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- NII Book ID
- AN10084591
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- ISSN
- 18812732
- 09135006
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- NDL BIB ID
- 032775479
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- Text Lang
- ja
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- Data Source
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- JaLC
- NDL
- Crossref
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- Abstract License Flag
- Disallowed