Correlation of Insulin Resistance and Lifestyle-related Diseases

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  • インスリン抵抗性と生活習慣病の相関関係
  • インスリン テイコウセイ ト セイカツ シュウカンビョウ ノ ソウカン カンケイ

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Abstract

<p>Objective: It has been recognized that there is a relationship between insulin resistance and lifestyle-related diseases. Therefore, this study aimed to examine the correlation between fasting immunoreactive insulin (F-IRI) and various examination levels in a medical checkup.</p><p>Methods: A total of 2,716 examinees in 8,504 cases with documented F-IRI levels were examined. Among these, medical checkup for 25,530 cases was carried out from 2016 to 2019.</p><p>Results: Body mass index, body fat percentage, waist circumference, diastolic blood pressure, fasting plasma glucose, homeostatic model assessment for insulin resistance, non-high-density lipoprotein cholesterol (n-HDL-C), HDL-C, triglyceride, aspartate aminotransferase, and alanine aminotransferase levels showed a significant correlation with F-IRI levels. We divided the examinees into four groups using the cluster analysis of the k-means method. The F-IRI levels progressed accordingly from the first group to the third group. The waist circumference of the third group was 94.8 ± 6.3 cm in men and 92.3 ± 8.3 cm in women. JMP pro ver. 14 for Windows was used for statistical analysis.</p><p>Conclusions: Our study demonstrates a significant correlation between F-IRI levels and various examination levels in a medical checkup. The cluster analysis results show that the third group is the target group, where specific health guidance should be performed.</p>

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