Clinical study on the efficacy of low-dose selective serotonin reuptake inhibitor (SSRI) therapy in the treatment of persistent postural-perceptual dizziness (PPPD)

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  • 持続性知覚性姿勢誘発めまいに対する少量セロトニン吸収阻害剤の有効性についての検討

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<p>The present study aimed to investigate the diseases preceding persistent postural-perceptual dizziness (PPPD) and the efficacy of low-dose selective serotonin reuptake inhibitor (SSRI) therapy in the treatment of PPPD. The Niigata PPPD Questionnaire (NPQ) was used to assess the efficacy of low-dose SSRI (sertraline [12.5 mg]) therapy. We also examined the adverse reactions to low-dose SSRI and the treatment continuation rate. PPPD was preceded by peripheral and central vestibular disease in 69.6% of cases, migraine-related dizziness in 17.4%of cases, orthostatic dysregulation in 11.6% of cases, and unknown conditions in 1.4% of cases. The efficacy rate of low-dose SSRI therapy in the treatment of PPPD was 75.9%. The incidence of adverse reactions was 23.1%, and the treatment continuation rate was 79.2%. The treatment continuation rate and efficacy rate of patients who received low-dose SSRI therapy were similar to those in previous reports with a reduced incidence of adverse reactions. Low-dose SSRI therapy is a promising treatment for PPPD.</p>

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  • jibi to rinsho

    jibi to rinsho 68 (4), 251-257, 2022-07-20

    JIBI TO RINSHO KAI

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