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Molecular Mechanism of “Charge Block-driven” Liquid-liquid Phase Separation and its Regulation by Phosphorylation
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- YAMAZAKI Hiroya
- Graduate School of Biostudies, Kyoto University
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- H. YOSHIMURA Shige
- Graduate School of Biostudies, Kyoto University
Bibliographic Information
- Other Title
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- 電荷ブロック型液－液相分離の仕組みとリン酸化による制御
- デンカ ブロックガタエキ-エキソウ ブンリ ノ シクミ ト リンサンカ ニ ヨル セイギョ
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Description
<p>Phosphorylation regulates protein function by altering stereospecific interaction with its substrate or partner proteins. However, recent studies demonstrated that phosphorylation preferably occurs in intrinsically disordered regions (IDRs), which do not have three-dimensional structures. Here, we describe how phosphorylation occurred in IDRs regulates the protein function. Mitotic phosphorylation in the IDRs of Ki-67 and NPM1 promotes or suppresses the liquid-liquid phase separation, respectively, by altering the “charge blockiness” along the polypeptide chain. The phosphorylation-mediated regulation of liquid-liquid phase separation by enhancing or suppressing “charge blockiness”, rather than by modulating stereospecific interaction, provides a new mechanism of protein regulation by post-translational modifications.</p>
Journal
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- Seibutsu Butsuri
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Seibutsu Butsuri 63 (3), 153-156, 2023
The Biophysical Society of Japan General Incorporated Association