Pancreas transplantation improves the quality of life of Japanese type 1 diabetes patients with diabetic kidney disease
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- Fujisawa-Tanaka Chika
- Department of Endocrinology, Diabetes and Metabolism, Fujita Health University, School of Medicine
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- Hiratsuka Izumi
- Department of Endocrinology, Diabetes and Metabolism, Fujita Health University, School of Medicine
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- Shibata Megumi
- Department of Endocrinology, Diabetes and Metabolism, Fujita Health University, School of Medicine
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- Kurihara Kei
- Department of Transplantation and Regenerative Medicine, Fujita Health University, School of Medicine
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- Aida Naohiro
- Department of Transplantation and Regenerative Medicine, Fujita Health University, School of Medicine
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- Takayanagi Takeshi
- Department of Endocrinology, Diabetes and Metabolism, Fujita Health University, School of Medicine
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- Seino Yusuke
- Department of Endocrinology, Diabetes and Metabolism, Fujita Health University, School of Medicine
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- Ito Taihei
- Department of Transplantation and Regenerative Medicine, Fujita Health University, School of Medicine
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- Kenmochi Takashi
- Department of Transplantation and Regenerative Medicine, Fujita Health University, School of Medicine
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- Suzuki Atsushi
- Department of Endocrinology, Diabetes and Metabolism, Fujita Health University, School of Medicine
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抄録
<p>Objectives: Type 1 diabetes mellitus (T1DM) patients with diabetic kidney disease-induced kidney failure have a significantly impaired quality of life (QOL), resulting in a high level of physical, mental, and social anxiety. In this study, we evaluated the QOL of T1DM patients on the list for pancreas transplantation (PTx) at their registration, and determined whether PTx improved their QOL.</p><p>Methods: There were 58 patients (men/women, 22/36; mean age, 42.8±8.0 years) with T1DM and who were registered on the waiting list for PTx. Quantitative QOL assessment was performed using the Medical Health Survey Short Form (SF-36) version 2. Changes in the QOL before and after PTx were also examined in 24 of these patients.</p><p>Results: The mean value of each endpoint and the summary score of the SF-36 physical (PCS), mental (MCS), and role (RCS) components were all below the national normal level at PTx registration. No significant difference in QOL scores was observed in the intergroup comparison of 35 patients on dialysis, 13 patients without dialysis, and ten patients after kidney transplantation. The 24 patients who underwent PTx showed improvement in PCS, MCS, and most SF-36 scores.</p><p>Conclusion: T1DM patients waiting for PTx had a decreased QOL, regardless of dialysis, and PTx improved their QOL.</p>
収録刊行物
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- Fujita Medical Journal
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Fujita Medical Journal 9 (3), 194-199, 2023
藤田医科大学医学会