Apolipoprotein E-associated Lipoprotein Glomerulo-tubulopathy
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- Tanimizu Hikaru
- Nephrology Center and Okinaka Memorial Institute for Medical Research, Toranomon Hospital Toranomon, Japan
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- Hara Risa
- Nephrology Center and Okinaka Memorial Institute for Medical Research, Toranomon Hospital Toranomon, Japan
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- Sekine Akinari
- Nephrology Center and Okinaka Memorial Institute for Medical Research, Toranomon Hospital Toranomon, Japan
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- Inoue Noriko
- Nephrology Center and Okinaka Memorial Institute for Medical Research, Toranomon Hospital Toranomon, Japan
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- Hasegawa Eiko
- Nephrology Center and Okinaka Memorial Institute for Medical Research, Toranomon Hospital Toranomon, Japan
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- Tanaka Kiho
- Nephrology Center and Okinaka Memorial Institute for Medical Research, Toranomon Hospital Toranomon, Japan
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- Kono Kei
- Department of Pathology, Toranomon Hospital Toranomon, Japan
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- Kinowaki Keiichi
- Department of Pathology, Toranomon Hospital Toranomon, Japan
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- Ohashi Kenichi
- Department of Pathology, Toranomon Hospital Toranomon, Japan Department of Human Pathology, Tokyo Medical Dental University, Japan
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- Okubo Minoru
- Section of Lipid Research and Department of Endocrinology and Metabolism, Toranomon Hospital, Japan
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- Yamaguchi Yutaka
- Yamaguchi's Pathology Laboratory, Japan
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- Kang Dedong
- Department of Anatomy, Showa University School of Medicine, Japan
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- Honda Kazuho
- Department of Anatomy, Showa University School of Medicine, Japan
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- Saito Takao
- Sanko Clinic, Japan
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- Sawa Naoki
- Nephrology Center and Okinaka Memorial Institute for Medical Research, Toranomon Hospital Toranomon, Japan
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- Ubara Yoshifumi
- Nephrology Center and Okinaka Memorial Institute for Medical Research, Toranomon Hospital Toranomon, Japan
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- Hoshino Junichi
- Nephrology Center and Okinaka Memorial Institute for Medical Research, Toranomon Hospital Toranomon, Japan
Abstract
<p>A 32-year-old man was admitted for the evaluation of proteinuria (5.69 g/day). A light microscopic examination showed markedly dilated glomerular capillary loops with vacuolated areas in many glomeruli, and vacuolated areas were seen on peritubular capillaries in the tubulointerstitium. When electron microscopy specimens prepared by pre-fixation with glutaraldehyde and post-fixation with osmium tetroxide were used for oil red staining, the deposition was confirmed on the affected areas. A genetic analysis of apoE showed that the lipoprotein glomerulopathy was due to apoE-Sendai (Arg145Pro, p.R163P) heterozygosity, which was found in not only the patient but also his mother and twin brother. </p>
Journal
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- Internal Medicine
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Internal Medicine 62 (15), 2209-2214, 2023-08-01
The Japanese Society of Internal Medicine
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Details 詳細情報について
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- CRID
- 1390859912502424064
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- ISSN
- 13497235
- 09182918
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- Text Lang
- en
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- Data Source
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- JaLC
- Crossref
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- Abstract License Flag
- Disallowed