The prognostic impact of different treatment intensities in older patients with endometrial cancer

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  • 高齢子宮体がん患者における治療強度が予後に与える影響
  • コウレイ シキュウタイ ガン カンジャ ニ オケル チリョウ キョウド ガ ヨゴ ニ アタエル エイキョウ

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Abstract

Objective : To examine the prognostic impact of different treatment intensities in older patients with endometrial cancer. Methods : Clinical data of patients aged over 70 years with endometrial cancer who underwent initial treatment between 2009 and 2018 were retrospectively reviewed. Standard treatment (ST) was defined as surgery with or without chemotherapy. Reduced treatment (RT) was defined as limited surgery or conversion to radiotherapy, or omission of chemotherapy. Results : Among 84 patients, 40 received ST and 44 opted for RT. There was no difference in the distribution of cancer stage, or histologic type. However, patients receiving RT were older (p < 0.0001) and had worse performance status (ECOG) (p = 0.003) compared to those receiving ST. For early-stage cancer, there was no difference in prognosis between treatment intensities, whereas for advanced cancer with high grade histology, the overall survival rate was significantly worse with RT (p = 0.03). Conclusion : This study revealed that about half of the elderly patients with endometrial cancer were treated with some form of reduced treatment. In early-stage cancer, reduced treatment intensity might have little impact on prognosis regardless of the histological grade. [Adv Obstet Gynecol, 75(3) : 241-248, 2023 (R5.8)]

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