Fatal invasive pneumococcal disease developed 14 years after allogeneic hematopoietic stem cell transplantation in a patient with myelodysplastic syndrome

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  • HOSODA Rina
    Department of Hematology, Tottori University Hospital
  • KAWAMURA Koji
    Department of Hematology, Tottori University Hospital Division of Clinical Laboratory Medicine, Department of Multidisciplinary Internal Medicine, School of Medicine, Tottori University Faculty of Medicine
  • HARA Kentaro
    Department of Hematology, Tottori University Hospital
  • MAEGAKI Masaya
    Department of Hematology, Tottori University Hospital
  • SUZUKI Sayaka
    Department of Hematology, Tottori University Hospital Division of Clinical Laboratory Medicine, Department of Multidisciplinary Internal Medicine, School of Medicine, Tottori University Faculty of Medicine
  • HOSODA Yuzuru
    Department of Hematology, Tottori University Hospital Division of Clinical Laboratory Medicine, Department of Multidisciplinary Internal Medicine, School of Medicine, Tottori University Faculty of Medicine
  • MORISHITA Shota
    Division of Clinical Laboratory, Tottori University Hospital
  • CHIKUMI Hiroki
    Department of Infectious diseases, Tottori University Hospital
  • MOTOKURA Toru
    Department of Hematology, Tottori University Hospital Division of Clinical Laboratory Medicine, Department of Multidisciplinary Internal Medicine, School of Medicine, Tottori University Faculty of Medicine
  • FUKUDA Tetsuya
    Department of Hematology, Tottori University Hospital

Bibliographic Information

Other Title
  • 骨髄異形成症候群に対する同種造血幹細胞移植14年後に発症した致死的侵襲性肺炎球菌感染症
  • コツズイイケイセイ ショウコウグン ニ タイスル ドウシュ ゾウケツ カンサイボウ イショク 14ネンゴ ニ ハッショウ シタ チシテキ シンシュウセイ ハイエン キュウキン カンセンショウ

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Abstract

<p>Invasive pneumococcal diseases (IPDs) after allogeneic hematopoietic stem cell transplantation have high fatality rates and often develop late after transplantation. The patient was a 58-year-old female. Fourteen years ago, she underwent bone marrow transplantation from a HLA-DR 1-antigen mismatched unrelated donor for myelodysplastic syndrome. She developed pneumonia, chronic graft-versus-host disease, and hypogammaglobulinemia. She received 23-valent pneumococcal capsular polysaccharide vaccine 11 and 6 years earlier. She was presented to our emergency room with fever. Her blood culture was positive for pneumococcus, and she was diagnosed with an IPD. The patient received antibiotic treatment but died on the third day of hospitalization. Because of its seriousness, pneumococcal infection should receive attention even 10 or more years after transplantation. Preventive approaches such as vaccination and early intervention at the time of diagnosis are important.</p>

Journal

  • Rinsho Ketsueki

    Rinsho Ketsueki 64 (7), 614-618, 2023

    The Japanese Society of Hematology

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