Perinatal management of pregnancies with congenital long QT syndrome

DOI
  • Onishi Yu
    Department of Obstetrics and Gynecology, Institute of Medicine, University of Tsukuba
  • Nishida Keiko
    Department of Obstetrics and Gynecology, Institute of Medicine, University of Tsukuba
  • Kosuge Yuki
    Department of Obstetrics and Gynecology, Institute of Medicine, University of Tsukuba
  • Suzuki Asuka
    Department of Obstetrics and Gynecology, Institute of Medicine, University of Tsukuba
  • Watanabe Makiko
    Department of Obstetrics and Gynecology, Institute of Medicine, University of Tsukuba
  • Hosokawa Yoshihiko
    Department of Obstetrics and Gynecology, Institute of Medicine, University of Tsukuba
  • Abe Haruna
    Department of Obstetrics and Gynecology, Institute of Medicine, University of Tsukuba
  • Mayumi Miyuki
    Department of Obstetrics and Gynecology, Institute of Medicine, University of Tsukuba
  • Ohara Rena
    Department of Obstetrics and Gynecology, Institute of Medicine, University of Tsukuba
  • Obata-Yasuoka Mana
    Department of Obstetrics and Gynecology, Institute of Medicine, University of Tsukuba
  • Murakami Takashi
    Department of Pediatrics, Institute of Medicine, University of Tsukuba
  • Takahashi Miho
    Department of Pediatrics, Institute of Medicine, University of Tsukuba Department of Pediatrics, Tsukuba Medical Center Hospital
  • Hamada Hiromi
    Department of Obstetrics and Gynecology, Institute of Medicine, University of Tsukuba
  • Satoh Toyomi
    Department of Obstetrics and Gynecology, Institute of Medicine, University of Tsukuba

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Other Title
  • 先天性QT延長症候群合併妊娠の周産期管理

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Abstract

<p> We retrospectively validated our management strategy of pregnancy with congenital long QT syndrome（LQTS）based on maternal beta-blocker therapy and fetal echocardiography/magnetocardiography. We reviewed the medical records of pregnant women with LQTS and their babies, who were delivered in 2019‒2022 at our institution. Ten pregnancies of eight women were included in the study. No cardiac events were observed in six women who were administered beta-blockers, whereas one of the four women who were not administered beta-blockers had a cardiac event at postpartum. Fetal magnetocardiography and echocardiography were performed in all 10 pregnancies, and fetal LQTS was suspected in 3 cases. All the women delivered under electrocardiogram monitoring, with two cesarean and eight vaginal deliveries. No light-for-gestational-age babies were identified, although five babies were diagnosed with LQTS. Our management strategy for pregnancies with LQTS might avoid adverse perinatal outcomes.</p>

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