Allergic fungal rhinosinusitis: What we can learn from allergic bronchopulmonary mycosis
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- Inoue Natsuki
- Department of Otorhinolaryngology, Toho University Ohashi Medical Center
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- Nakayama Tsuguhisa
- Department of Otorhinolaryngology and Head & Neck Surgery, Dokkyo Medical University
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- Ueki Shigeharu
- Department of General Internal Medicine and Clinical Laboratory Medicine, Akita University Graduate School of Medicine
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- Miyata Jun
- Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine
書誌事項
- 公開日
- 2023
- 資源種別
- journal article
- DOI
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- 10.1016/j.alit.2023.06.005
- 公開者
- 一般社団法人日本アレルギー学会
この論文をさがす
説明
<p>Allergic fungal rhinosinusitis (AFRS) and allergic bronchopulmonary mycosis (ABPM) are inflammatory disorders of the respiratory tract resulting from type 1 and 3 hypersensitivity reactions against fungi. The hallmark features of both diseases are eosinophil infiltration into the airway mucosa caused by localized type 2 inflammation and concomitant viscid secretions in the airways. Eosinophilic mucin-induced compression of adjacent anatomic structures leads to bone erosion and central bronchiectasis in the upper and lower respiratory tracts, respectively. Although these diseases share common features in their pathogenesis, they also exhibit notable differences. Epidemiologic findings are diverse, with AFRS typically presenting at a younger age, exhibiting less complicated bronchial asthma, and displaying lower total immunoglobulin E levels in laboratory findings compared with ABPM. Furthermore, despite their similar pathogenesis, the rarity of sinio-bronchial allergic mycosis in both AFRS and ABPM underscores the distinctions between these two diseases. This review aims to clarify the similarities and differences in the pathogenesis of AFRS and ABPM to determine what can be learned about AFRS from ABPM, where more is known.</p>
収録刊行物
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- Allergology International
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Allergology International 72 (4), 521-529, 2023
一般社団法人日本アレルギー学会
