Wearable Biosensor Utilizing Chitosan Biopolymer for Uric Acid Monitoring

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  • Sato Mizuki
    Graduate School of Engineering, Tokyo University of Technology
  • Kamiyama Tatsuya
    Department of Electric and Electronic Engineering, School of Engineering, Tokyo University of Technology
  • Iitani Kenta
    Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University
  • Yano Kazuyoshi
    Graduate School of Bionics, Computer and Media Sciences, Tokyo University of Technology
  • Mitsubayashi Kohji
    Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University
  • Arakawa Takahiro
    Graduate School of Engineering, Tokyo University of Technology Department of Electric and Electronic Engineering, School of Engineering, Tokyo University of Technology

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<p>A wearable biosensor was specifically engineered to measure uric acid, a biomarker present at wound sites. This biosensor, fabricated as a disposable and wearable device, was seamlessly integrated onto a polyethylene terephthalate (PET) substrate by utilizing carbon and silver conductive paste as the electrodes. The enzyme uricase was immobilized onto the working electrode by utilizing chitosan, a biocompatible material, to create this biosensor. Notably, the uric acid biosensor fabricated with chitosan showcased exceptional performance metrics, including remarkable output current values and impeccable stability. These findings suggest the prospective utilization of chitosan-based uric acid biosensors for the accurate measurement of uric acid on human skin in future applications.</p>

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