Effects of Fractional Flow Reserve on Coronary Artery Bypass Graft Flow to Left Anterior Descending Artery

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  • Takami Yoshiyuki
    Department of Cardiovascular Surgery, Fujita Health University School of Medicine
  • Maekawa Atsuo
    Department of Cardiovascular Surgery, Fujita Health University School of Medicine
  • Yamana Koji
    Department of Cardiovascular Surgery, Fujita Health University School of Medicine
  • Akita Kiyotoshi
    Department of Cardiovascular Surgery, Fujita Health University School of Medicine
  • Amano Kentaro
    Department of Cardiovascular Surgery, Fujita Health University School of Medicine
  • Sakurai Yusuke
    Department of Cardiovascular Surgery, Fujita Health University School of Medicine
  • Matsuhashi Kazuki
    Department of Cardiovascular Surgery, Fujita Health University School of Medicine
  • Niwa Wakana
    Department of Cardiovascular Surgery, Fujita Health University School of Medicine
  • Takagi Yasushi
    Department of Cardiovascular Surgery, Fujita Health University School of Medicine

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Abstract

<p>Background: The relationships between preoperative fractional flow reserve (FFR) values of the left anterior descending artery (LAD), FFRLAD, and intraoperative transit time flow measurement (TTFM) variables in coronary artery bypass grafting (CABG) remain unclear.</p><p>Methods and Results: We retrospectively collected data for 74 in situ left internal thoracic artery (LITA) grafts and 27 saphenous vein grafts (SVGs) to the LAD that were shown to be patent on postoperative angiography. Spearman correlation coefficients were determined between FFRLADand TTFM parameters of the LITA graft, as follows: maximum flow (Qmax), −0.22 (P=0.077); minimum flow (Qmin), −0.40 (P=0.014); mean flow (Qm), −0.35 (P=0.039); pulsatility index (PI), 0.33 (P=0.008); diastolic filling (DF): 0.01 (P=0.83); and systolic reverse flow (SRF), 0.37 (P=0.002). Spearman correlation coefficients between FFRLADand TTFM parameters of the SVG to LAD were: Qmax, −0.65 (P=0.004); Qmin, −0.43 (P=0.044); Qm, −0.75 (P=0.001); PI, 0.53 (P=0.033); DF, 0.14 (P=0.48); and SRF, 0.61 (P=0.009).</p><p>Conclusions: Both LITA grafts and SVGs to the LAD show negative correlations for FFRLADwith Qminand Qm, but positive correlations for FFRLADwith PI and SFR. These relationships between FFRLADand TTFM variables of CABG grafts to the LAD should be recognized.</p>

Journal

  • Circulation Journal

    Circulation Journal 87 (11), 1672-1679, 2023-10-25

    The Japanese Circulation Society

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