Antifungal effect of <i>Moringa oleifera</i> leaf extract on <i>Candida albicans</i>

DOI
  • YOSHIMATSU Hideki
    Department of Preventive and Community Dentistry, Osaka Dental University
  • TANAKA Reiji
    Fourth year student, School of Dentistry, Osaka Dental University
  • KAWAMURA Kahori
    Department of Preventive and Community Dentistry, Osaka Dental University
  • HUANG Zheqi
    Department of Preventive and Community Dentistry, Osaka Dental University Graduate School of Dentistry (Department of Preventive and Community Dentistry), Osaka Dental University
  • KAMADA Sayuri
    Department of Preventive and Community Dentistry, Osaka Dental University Graduate School of Dentistry (Department of Preventive and Community Dentistry), Osaka Dental University
  • FUKUHARA Takahisa
    Department of Preventive and Community Dentistry, Osaka Dental University
  • KANO Keita
    Department of Preventive and Community Dentistry, Osaka Dental University
  • DOI Takashi
    Department of Preventive and Community Dentistry, Osaka Dental University
  • MIYAKE Tatsuro
    Department of Preventive and Community Dentistry, Osaka Dental University

抄録

<p>Candida albicans is a common pathogen, especially in immunocompromised patients. What is concerning is that this pathogen is displaying increasing resistance to azole drugs, which are commonly used to treat it. We investigated the antifungal activity of Moringa oleifera leaves against C. albicans. The fungicidal effect of C. albicans exposed to Moringa oleifera leaves was determined using adenosine triphosphate (ATP) bioluminescence. Moringa oleifera leaves showed antifungal activity against C. albicans with a minimum inhibitory concentration (MIC) of 50 μg/mL. Additionally, at the MIC, the Moringa oleifera leaves significantly reduced ATP-leakage. This study provides sufficient evidence of the in vitro antifungal effects of Moringa oleifera leaves against C. albicans. (J Osaka Dent Univ 2023; 57: 295-299)</p>

収録刊行物

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詳細情報 詳細情報について

  • CRID
    1390860852414660736
  • DOI
    10.18905/jodu.57.2_295
  • ISSN
    21896488
    04752058
  • 本文言語コード
    en
  • データソース種別
    • JaLC
  • 抄録ライセンスフラグ
    使用不可

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