Association between Eicosapentaenoic Acid to Arachidonic Acid Ratio and Characteristics of Plaque Rupture
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- Sekimoto Teruo
- Division of Cardiology, Department of Medicine, Showa University School of Medicine Division of Cardiology, Department of Medicine, Showa University Fujigaoka Hospital
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- Koba Shinji
- Division of Cardiology, Department of Medicine, Showa University School of Medicine Division of General Medicine, Department of Perioperative Medicine, Showa University School of Dentistry
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- Mori Hiroyoshi
- Division of Cardiology, Department of Medicine, Showa University Fujigaoka Hospital
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- Arai Taito
- Division of Cardiology, Department of Medicine, Showa University School of Medicine
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- Yamamoto Myong Hwa
- Clinical Research Institute for Clinical Pharmacology and Therapeutics Showa University
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- Mizukami Takuya
- Clinical Research Institute for Clinical Pharmacology and Therapeutics Showa University
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- Matsukawa Naoki
- Department of Legal Medicine, Showa University School of Medicine
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- Sakai Rikuo
- Division of Cardiology, Department of Medicine, Showa University School of Medicine
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- Yokota Yuya
- Division of Cardiology, Department of Medicine, Showa University School of Medicine
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- Sato Shunya
- Division of Cardiology, Department of Medicine, Showa University School of Medicine
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- Tanaka Hideaki
- Division of Cardiology, Department of Medicine, Showa University School of Medicine
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- Masaki Ryota
- Division of Cardiology, Department of Medicine, Showa University School of Medicine
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- Oishi Yosuke
- Division of Cardiology, Department of Medicine, Showa University School of Medicine
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- Ogura Kunihiro
- Division of Cardiology, Department of Medicine, Showa University School of Medicine
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- Arai Ken
- Division of Cardiology, Department of Medicine, Showa University School of Medicine
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- Nomura Kosuke
- Division of Cardiology, Department of Medicine, Showa University School of Medicine
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- Sakai Koshiro
- Division of Cardiology, Department of Medicine, Showa University School of Medicine
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- Tsujita Hiroaki
- Division of Cardiology, Department of Medicine, Showa University School of Medicine
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- Kondo Seita
- Division of Cardiology, Department of Medicine, Showa University School of Medicine
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- Tsukamoto Shigeto
- Division of Cardiology, Department of Medicine, Showa University School of Medicine
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- Suzuki Hiroshi
- Division of Cardiology, Department of Medicine, Showa University Fujigaoka Hospital
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- Shinke Toshiro
- Division of Cardiology, Department of Medicine, Showa University School of Medicine
説明
<p> Aims: Eicosapentaenoic acid (EPA) has shown beneficial effects on coronary plaque stabilization. Based on our previous study, we speculated that EPA might be associated with the development of healed plaques and might limit thrombus size. This study aimed to elucidate the association between EPA and arachidonic acid (AA) ratios and various plaque characteristics in patients with plaque rupture.</p><p>Methods: A total of 95 patients with acute coronary syndrome (ACS) caused by plaque rupture who did not take lipid-lowering drugs and underwent percutaneous coronary intervention using optical coherence tomography (OCT) were included. Clinical characteristics, lipid profiles, and OCT findings were compared between patients with lower and higher EPA/AA ratios (0.41) according to the levels in the Japanese general population.</p><p>Results: In the high EPA/AA (n=29, 30.5%) and low EPA/AA (n=66, 69.5 %) groups, the high EPA/AA group was significantly older (76.1 vs. 66.1 years, P＜0.01) and had lower peak creatine kinase (556 vs. 1651 U/L, P=0.03) than those with low EPA/AA. Similarly, patients with high EPA/AA had higher prevalence of layered and calcified plaque (75.9 vs. 39.4 %, P＜0.01; 79.3 vs. 50.0 %, P＜0.01, respectively) than low EPA/AA group. Multivariate logistic regression analysis demonstrated that a high EPA/AA ratio was an independent factor in determining the development of layered and calcified plaques.</p><p> Conclusion: A high EPA/AA ratio may be associated with the development of layered and calcified plaques in patients with plaque rupture.</p>
収録刊行物
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- Ｊｏｕｒｎａｌ ｏｆ Ａｔｈｅｒｏｓｃｌｅｒｏｓｉｓ ａｎｄ Ｔｈｒｏｍｂｏｓｉｓ
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Ｊｏｕｒｎａｌ ｏｆ Ａｔｈｅｒｏｓｃｌｅｒｏｓｉｓ ａｎｄ Ｔｈｒｏｍｂｏｓｉｓ 30 (11), 1687-1702, 2023-11-01
一般社団法人 日本動脈硬化学会