Patient with Diffuse Midline Glioma, H3 K27-altered, Carrying an <i>FGFR1</i> Mutation Who Experienced Thalamic Hemorrhage: A Case Report and Literature Review
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- MATSUNAGA Kyosuke
- Department of Neurosurgery, Tokyo Medical University Hospital
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- FUKAMI Shinjiro
- Department of Neurosurgery, Tokyo Medical University Hospital
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- NAKAJIMA Nobuyuki
- Department of Neurosurgery, Tokyo Medical University Hospital
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- ICHIMASU Norio
- Department of Neurosurgery, Tokyo Medical University Hospital
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- KOHNO Michihiro
- Department of Neurosurgery, Tokyo Medical University Hospital
抄録
<p>Diffuse midline glioma (DMG), H3 K27M-altered, is a tumor with a poor prognosis mainly found in children. An adolescent patient presented with thalamic hemorrhage, which initially could not be diagnosed as DMG by pathological analysis. A neoplasm in the lateral ventricle close to the previous thalamic hemorrhagic lesion was detected 12 months after the hemorrhage. Thus, endoscopic resection was performed, and a diagnosis was made. Gene expression profiling demonstrated mutation in genes, such as H3F3A and FGFR1. FGFR1 mutation was associated with intratumoral hemorrhage in low-grade gliomas and contributed to longer survival than wild-type FGFR1 in DMG H3K27M. Our findings suggest that patients with DMG, H3 K27-altered, with FGFR1 mutation may be predisposed to intratumoral hemorrhaging and/or have a longer survival time than patients without FGFR1 mutation.</p>
収録刊行物
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- NMC Case Report Journal
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NMC Case Report Journal 10 (0), 309-314, 2023-12-31
一般社団法人 日本脳神経外科学会
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詳細情報 詳細情報について
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- CRID
- 1390861074211209984
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- ISSN
- 21884226
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- Crossref
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- 抄録ライセンスフラグ
- 使用不可