A Case of Obstructing Bronchial Aspergillosis in a Patient Receiving Cytotoxic Chemotherapy and Inhaled Corticoid Therapy

DOI DOI Web Site 参考文献13件 オープンアクセス
  • Tsuneoka Yuki
    Department of Respiratory Medicine, Graduate School of Medical Sciences, Kyushu University
  • Tanaka Kentaro
    Department of Respiratory Medicine, Graduate School of Medical Sciences, Kyushu University
  • Shimauchi Atsushi
    Department of Respiratory Medicine, Graduate School of Medical Sciences, Kyushu University
  • Inoue Shigesato
    Department of Respiratory Medicine, Graduate School of Medical Sciences, Kyushu University
  • Yoneshima Yasuto
    Department of Respiratory Medicine, Graduate School of Medical Sciences, Kyushu University
  • Ikegame Satoshi
    Department of Respiratory Medicine, Graduate School of Medical Sciences, Kyushu University
  • Harada Eiji
    Department of Respiratory Medicine, Kitakyushu Municipal Medical Center
  • Okamoto Isamu
    Department of Respiratory Medicine, Graduate School of Medical Sciences, Kyushu University

説明

<p>Among various types of aspergillosis, the clinical features of patients with obstructive bronchial aspergillosis remain unclear. Originally, it was reported to occur only in severely immunocompromised patients, such as acquired immunodeficiency syndrome (AIDS) or post-organ transplantation; however, recent reports have suggested that this disease could also affect patients seen in daily practice of pulmonary medicine. We describe a case of a 76-year-old woman with obstructing bronchial aspergillosis. This patient presented to the hospital with a productive cough during asthma and advanced lung cancer treatment. Chest CT showed stenosis of the bronchial lumen. Bronchoscopy showed no recurrence of lung cancer, and aspergillus was found in the granulation tissue. The cough improved with debridement of the lesion by bronchoscopy and oral antifungal medication treatment. Our review of previous case reports, including this case, revealed that obstructing bronchial aspergillosis might occur when patients have several factors inducing immunosuppression, such as solid tumors under anticancer treatment, inhaled corticosteroids, and aging. Since patients may be at risk of progressing to invasive aspergillosis, physicians must properly diagnose obstructing bronchial aspergillosis to deliver appropriate treatment.</p>

収録刊行物

  • Respiratory Endoscopy

    Respiratory Endoscopy 1 (2), 105-108, 2023-11-29

    一般社団法人 日本呼吸器内視鏡学会

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