Chronic Progression of Intraductal Papillary Mucinous Carcinoma Accompanied by Stromal Ossification

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  • 経時的に観察しえた骨化生を伴う膵管内乳頭粘液性癌の1例

Abstract

<p>An 81-year-old male was found to have a cystic tumor of 20 mm in diameter with calcification in the uncinate process of the pancreas on CT. The tumor increased to 33 mm in diameter over 5 years, with diffuse calcification inside the tumor. Upper gastrointestinal endoscopy showed a papillary tumor invading the third portion of the duodenal wall. Invasive intraductal papillary mucinous carcinoma (IPMC) was diagnosed and subtotal stomach-preserving pancreatoduodenectomy was performed. Pathologically, IPMC tumor cells were detected in the main pancreatic duct invading the duodenal wall. Osseous metaplasia was mainly seen in the stroma surrounding the non-invasive area of IPMC. The patient is alive with no recurrence at 7 months after surgery. We report this case with a review of the literature on etiology of osteogenesis accompanied by IPMC. Further accumulation of clinical cases is needed to improve understanding of this rare condition.</p>

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