Outcome and rehospitalization rates of patients with decompensated cirrhosis showing hepatic encephalopathy

DOI Web Site

Bibliographic Information

Other Title
  • 非代償性肝硬変に伴う肝性脳症の再入院率と予後
  • ヒダイショウセイ カンコウヘン ニ トモナウ カンセイ ノウショウ ノ サイニュウインリツ ト ヨゴ

Search this article

Abstract

<p>Patients with decompensated cirrhosis are at the high risk for rehospitalization even when hepatic encephalopathy attenuated during the admission. Thus, the survival rates and rehospitalization rates were evaluated in patients with hepatic encephalopathy retrospectively, and factors associated with the readmission were identified. Subjects were a total of 85 consecutive cirrhotic patients diagnosed as having hepatic encephalopathy and hospitalized in our hospital from January 2009 to June 2017. They consisted of 42 men and 43 women, with a median age of 73.7 years, and the Child-Pugh class C liver damage and hepatocellular carcinoma (HCC) were seen in 64 patients and 29 patients, respectively. During the median follow-up period for 178 days, 14 patients died during the hospitalization, Of 71 patients achieving discharge from the hospital, 51 patients were readmitted for the treatment of recurrent hepatic encephalopathy. The cumulative rehospitalization rates at 1 and 3 months were 27.4％ and 45.8％, respectively. Univariate analysis demonstrated that the Child-Pugh score of 12 or more (p＝0.007) and presence of HCC were factors associated with the readmission (p＝0.007 and p＝0.04, respectively). Multivariate analysis, however, revealed that the Child-Pugh score of 12 or more as an exclusive significant factor associated with the readmission (HR＝2.26, 95％CI 1.28-3.99, p＝0.005). The cumulative survival rate of these patients was 49.7％ at 1 year, and the outcome of those with HCC was unfavorable than in the remaining patients (p＜0.001). Cirrhotic patients who achieve discharge from the hospital following attenuation of hepatic encephalopathy should be observed carefully to prevent readmission due to recurrent encephalopathy.</p>

Journal

Keywords

Details 詳細情報について

Report a problem

Back to top