Utility of LA1c+ for Screening <i>δ</i>-chain Variant Hemoglobin, Hb A2-Niigata

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  • Ito Mika
    Department of Diabetes and Endocrinology, Saiseikai Toyama Hospital
  • Shikata Masataka
    Department of Diabetes and Endocrinology, Saiseikai Toyama Hospital
  • Koga Masafumi
    Department of Internal Medicine, Hakuhokai Central Hospital

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Other Title
  • HbA1c/LA1c＋比は異常ヘモグロビンHb A2-Niigataのスクリーニング検査に有用である

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Abstract

<p>We reported multiple cases of Hb A2-Niigata with δ-chain variant hemoglobin triggered by falsely high HbA1c levels measured using high-performance liquid chromatography (HPLC). We compared the HbA1c and LA1c+levels measured by HPLC (HLC-723 G9) in 5 subjects with Hb A2-Niigata with those of 50 non-diabetic and 50 diabetic controls. The HbA1c levels in subjects with Hb A2-Niigata were significantly higher than those in non-diabetic subjects, but there was no significant difference from diabetic subjects. In contrast, their LA1c+levels showed no significant difference from the non-diabetic subjects but were significantly lower than the values in diabetic subjects. The HbA1c/LA1c+ratio in subjects with Hb A2-Niigata was significantly higher than that of non-diabetic or diabetic controls. When the cutoff value of the HbA1c/LA1c+ratio was set to 3, it was possible to diagnose Hb A2-Niigata with high sensitivity and specificity. For cases where falsely high HbA1c levels are suspected, the HbA1c/LA1c+ratio is useful for first-line screening of δ-chain variant hemoglobin, Hb A2-Niigata.</p>

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