Development of Functional Compounds Using Chemically Unstable Compounds Obtained from Medicinal Plants

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  • 薬用植物から得られる化学的に不安定な成分を使用した機能性化合物の開発研究

Abstract

<p>Sulfur- or nitrogen-containing compounds from medicinal plants exhibit various biological activities such as anticancer potential. Developing efficient strategies to isolate or synthesize these compounds or their derivatives is a remarkable achievement. We have isolated several sulfur-containing compounds such as tetrahydro-2H-difuro[3,2-b:2′,3′-c]furan-5(5aH)-one derivatives from Allium plants. We have devised a unique approach for the rapid preparation of thiopyranones using the regioselective sequential double Diels–Alder reaction; we used a naturally-occurring chemically-unstable intermediate such as thioacrolein, which is produced from allicin, a major component in garlic. The cytotoxicity of the synthetic thiopyranones against cancer stem cells (CSCs) was equal to or higher than that of (Z)-ajoene, the reference compound.</p>

Journal

  • YAKUGAKU ZASSHI

    YAKUGAKU ZASSHI 144 (1), 21-26, 2024-01-01

    The Pharmaceutical Society of Japan

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