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- 山田 智也
- 住友化学・生物環境科学研究所
書誌事項
- タイトル別名
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- Chemical-induced perinatal thyroid hormone disruption and brain developmental adversity
抄録
<p>Thyroid hormones (THs) are essential for proper nervous system development. Environmental chemicals that disrupt the thyroid system are of regulatory concern for potential adverse effects on the developing brain. However, since quantitative relationships between chemical-induced perinatal TH insufficiency and abnormal brain development have not been fully understood, OECD test guidelines were revised in 2018 to make measurement of peripheral TH levels mandatory in toxicity studies. If test chemical disrupts TH levels, then developmental neurotoxicity (DNT) should be assessed. Since studies to identify DNT are comprehensive and require substantial resources, a simple screening test is needed. We focused on a weight-of-evidence approach based on mode of action using a short-term in vivo study, the “Comparative Thyroid Assay (CTA)” in rats, and began verifying the feasibility of an augmented CTA by adding parameters (brain TH levels and brain histopathology) but reducing the number of rats. Our findings suggest that the augmented CTA can be a potential short-term in vivo assay for sorting perinatal TH disruptors. In addition to this, the augmented CTA can also be used for collecting data to build a model of physiologically based pharmacokinetics (PBPK) in the perinatal period, intended to utilizing new approach methodologies (NAMs).</p>
収録刊行物
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- 日本薬理学会年会要旨集
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日本薬理学会年会要旨集 97 (0), 1-B-S16-2-, 2023
公益社団法人 日本薬理学会
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詳細情報 詳細情報について
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- CRID
- 1390861692692065920
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- ISSN
- 24354953
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- Crossref
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- 抄録ライセンスフラグ
- 使用不可