フェルラ酸誘導体は光血栓性脳卒中ラットの血液脳関門障害を軽減する

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  • FAD012 reduces blood-brain-barrier damage in photothrombotic stroke rats.

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<p>Stroke often causes severe sequelae and reduces the quality of life of patients, therefore effective preventive and therapeutic methods are desired. FAD012, a ferulic acid derivative (FAD), is derived from ferulic acid (FA) and has been shown to be potentially effective in preventing cerebral infarctionin middle cerebral artery occlusion following reperfusion (MCAO/Re) rats. In this study, we investigated the protective effects of FAD012 on blood- brain-barrier (BBB) damage using photothrombotic stroke rats.　</p><p>Under isoflurane anesthesia, a bone window was opened in the left temporal bone of male Sprague Dawley rats to expose the MCA. The MCA was irradiated with green laser light and Rose Bengal was administered intravenously to form a local thrombus. FAD012 was administered intraperitoneally 1 h before laser irradiation. To evaluate BBB damage, Evans blue (EB) staining and immunostaining of collagen IV and claudin V, which are factors that constitute tight junctions (TJs), were performed.</p><p>Histochemistry revealed extensive infarction and BBB damage in the left parietal lobe of the control group. Furthermore, collagen IV and claudin V were significantly decreased in the infarct area. In FAD012 group, BBB damage and reduction in these factors were suppressed. These results suggest that FAD012 protects BBB damage in the ischemic region and that protection of TJs is involved in its cerebroprotective effects.</p>

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