書誌事項
- タイトル別名
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- Brain α7 nicotinic receptor stimulation inhibits the rat micturition via brain hydrogen sulfide
抄録
<p>We recently reported that brain α7 nicotinic receptor (α7 nAChR) stimulation and brain hydrogen sulfide (H2S) inhibited the rat micturition. In this study, we examined whether brain H2S is involved in the micturition inhibition induced by brain α7 nAChR stimulation in urethane-anesthetized (0.8 g/kg, ip) male Wistar rats. A catheter was inserted into the bladder to perform cystometry (12 ml/h saline infusion). We examined effects of intracerebroventricularly (icv) pretreated GYY4137 (GYY, H2S donor, 1 or 3 nmol/rat) or AOAA (non-selective inhibitor of H2S synthesis, 3 or 10 μg/rat) on PHA568487 (PHA, α7 nAChR agonist, 0.3 or 1 nmol/rat, icv)-induced prolongation of intercontraction intervals (ICI), an index of micturition frequency. PHA (0.3 nmol/rat) showed no significant effect on ICI, while under pretreatment with GYY, PHA significantly prolonged ICI even at a lower dose (0.3 nmol/rat). PHA (1 nmol/rat) induced ICI prolongation and the PHA-induced prolongation was significantly suppressed by AOAA. The AOAA-induced suppression of the PHA-induced ICI prolongation was cancelled by supplementation of brain H2S via GYY. These data suggest that brain α7 nAChR stimulation inhibits the rat micturition via brain H2S.</p>
収録刊行物
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- 日本薬理学会年会要旨集
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日本薬理学会年会要旨集 97 (0), 3-B-P-032-, 2023
公益社団法人 日本薬理学会
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詳細情報 詳細情報について
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- CRID
- 1390861692692556800
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- ISSN
- 24354953
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- Crossref
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- 抄録ライセンスフラグ
- 使用不可