血液脳関門を効率的に通過するナノマシンの開発

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  • Development of blood-brain barrier crossing nanomachine

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<p>The nano-structured systems that transport bioactive substances to a target location in the body have recently attracted much attention and have been rapidly advancing. However, none of these systems have been able to enter the brain via a systemic route beyond the blood-brain barrier (BBB) to reach the neurons efficiently. Taking advantage of the phenomenon that transporter-1, which is expressed at a very high level in the brain capillary endothelial cells (BCECs), migrates from the luminal side to the abluminal side in response to a rapid increase of blood glucose concentration from the hypoglycemic state, we succeeded in accumulating a self-assembled supramolecular nanocarrier with glucose integrated on the surface with optimal configuration in the brain, with significant efficiency. Precise control of glucose density on the surface of the nanocarrier allowed selection of the accumulation point in the brain, and a particularly high degree of accumulation in the neurocytes was achieved. In this presentation, we will introduce recent research that is developing a treatment for neurological diseases together with nanocarrier that passes through the BBB with nearly 100 times higher efficiency than existing technologies.</p>

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