Effects of Various Antibiotics on Cell Viability and Angiogenesis
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- NAKAI Mariko
- Department of Forensic Dentistry, School of Dentistry, Osaka Dental University, Osaka, Japan
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- HASHIMOTO Yoshiya
- Department of Biomaterials, School of Dentistry, Osaka Dental University, Osaka, Japan
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- KUBOTA Tsutomu
- Department of Biomaterials, School of Dentistry, Osaka Dental University, Osaka, Japan
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- IMAI Koichi
- Department Tissue Engineering, School of Dentistry, Osaka Dental University, Osaka, Japan
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- OKUSA Nobutaka
- Department of Forensic Dentistry, School of Dentistry, Osaka Dental University, Osaka, Japan
Abstract
<p>The issues of antimicrobial susceptibility and biosafety are supposed to be complcated. Angiogenesis is one of the most important factors in wound healing. Therefore, we focused on three antibiotics that are known to have a certain effects on periodontopathogenic bacteria and infected root canal bacteria, and exposed cultured cells to these antibiotics to examine their effects on cell viability and angiogenesis. The cell viability was reduced by less than half in all three samples used in this study at concentrations higher than 0.5 mg/mL. During wound healing, angiogenesis occurs through the interaction of fibroblasts, vascular endothelial cells, and other cells. Thus, the possibility that antimicrobial components dissolved in saliva might delay the wound healing cannot be excluded. The balance between antimicrobial potency, physical properties, and biological safety must be considered when using antibiotics.</p>
Journal
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- Journal of Oral Tissue Engineering
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Journal of Oral Tissue Engineering 21 (2), 66-73, 2023
Japanese Association of Regenerative Dentistry
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Keywords
Details 詳細情報について
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- CRID
- 1390861781429129984
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- ISSN
- 18800823
- 13489623
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- Text Lang
- en
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- Data Source
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- JaLC
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- Abstract License Flag
- Disallowed