Association of Autonomic Activity With Sleep Disturbances in Early, Middle, and Late Pregnancy by Longitudinal Study

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  • 縦断調査による妊娠初期,中期,後期の睡眠障害と自律神経活動との関連
  • ジュウダン チョウサ ニ ヨル ニンシン ショキ,チュウキ,コウキ ノ スイミン ショウガイ ト ジリツ シンケイ カツドウ ト ノ カンレン

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<p>Objective: To conduct serial measurement of subjective and objective sleep indices in pregnant women to determine the relationship between autonomic nervous system activity and sleep disturbances over the course of pregnancy.</p><p>Method: Subjective sleep indices (Pittsburgh Sleep Quality Index [PSQI-J], Epworth Sleepiness Scale [JESS]), objective sleep indices, and autonomic nervous activity were measured in pregnant women using a Silmee Bar type Lite biosensor in each of early, middle, and late pregnancy. Overnight mean values of high-frequency (HF) as a measure of parasympathetic activity and overnight mean values of low-frequency (LF)/HF ratio as a measure of sympathetic activity were used in the analysis.</p><p>Results: Thirty-seven patients were included in the analysis. PSQI-J scores were significantly lower in the middle period than in the early periods. Regarding autonomic activity, mean HF was significantly higher in the early period and mean LF/mean HF was significantly lower in the early period. In the late period, positive correlations were found between PSQI-J score and mean LF/mean HF, as well as between JESS score and mean LF/mean HF, and negative correlations were found between PSQI-J score and mean HF, as well as between JESS score and mean HF.</p><p>Conclusion: The present findings suggest that autonomic nervous system activity may be a contributing factor to sleep disturbances in pregnant women.</p>

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