Comparison of Characteristics and Outcomes Between Acute Ischemic Stroke Patients with Different Types of Heart Failure
-
- Wu Jiongxing
- Department of Neurology, West China Hospital, Sichuan University Center for Cerebrovascular Diseases, West China Hospital, Sichuan University
-
- Chen Mingxi
- Department of Neurology, West China Hospital, Sichuan University Center for Cerebrovascular Diseases, West China Hospital, Sichuan University
-
- Wang Huan
- Department of Neurology, West China Hospital, Sichuan University Center for Cerebrovascular Diseases, West China Hospital, Sichuan University
-
- Zhu Yuyi
- Department of Neurology, West China Hospital, Sichuan University Center for Cerebrovascular Diseases, West China Hospital, Sichuan University
-
- Chen Yaqi
- Department of Neurology, West China Hospital, Sichuan University Center for Cerebrovascular Diseases, West China Hospital, Sichuan University
-
- Zhang Shihong
- Department of Neurology, West China Hospital, Sichuan University Center for Cerebrovascular Diseases, West China Hospital, Sichuan University
-
- Wang Deren
- Department of Neurology, West China Hospital, Sichuan University Center for Cerebrovascular Diseases, West China Hospital, Sichuan University
抄録
<p>Acute ischemic stroke (AIS) can be complicated by heart failure involving preserved ejection fraction (HFpEF) or reduced ejection fraction (HFrEF), and whether or not the prognosis differs between the 2 types of patients remains unclear. We compared the clinical characteristics and outcomes of the 2 types of patients at 3 months after the stroke.</p><p>We retrospectively analyzed patients who, between 1 January 2018 and 1 January 2021, experienced AIS that was complicated by HFrEF or HFpEF. All patients had been prospectively registered in the Chengdu Stroke Registry. Poor outcome was defined as a modified Rankin Scale (mRS) score of 2-6 at 3 months. Univariate and binary logistic regression was used to assess whether HFpEF was associated with a significantly worse prognosis than HFrEF.</p><p>Among the final sample of 108 patients (60.2% men; mean age, 73.08 ± 10.82 years), 75 (69.4%) had HFpEF. Compared to HFrEF patients, those with HFpEF were older (P = 0.002), were more likely to have chronic kidney disease (P = 0.033), and were more likely to experience a poor outcome (P = 0.022). After adjustments, HFpEF was associated with significantly greater risk of poor outcome than HFrEF (OR 4.13, 95%CI 1.20-15.79, P = 0.029). However, rates of hemorrhagic transformation or mortality at 3 months after AIS did not differ significantly between the 2 types of heart failure (all P > 0.05).</p><p>Patients with AIS involving HFpEF experience worse outcomes than those with HFrEF and therefore may require special monitoring and management. Our findings need to be verified in large prospective studies.</p>
収録刊行物
-
- International Heart Journal
-
International Heart Journal 65 (1), 94-99, 2024-01-31
一般社団法人 インターナショナル・ハート・ジャーナル刊行会