Characterization of CTX-M-22 and TEM-141 encoded by a single plasmid from a clinical isolate of Enterobacter cloacae in China

  • Liu Gang
    Pharmaceutical Research Institute and Department of Pharmacology, North Sichuan Medical College, China National Engineering Research Center for Biomaterials, Sichuan University, China
  • Ling Bao-Dong
    Pharmaceutical Research Institute and Department of Pharmacology, North Sichuan Medical College, China
  • Xie Yong-En
    Pharmaceutical Research Institute and Department of Pharmacology, North Sichuan Medical College, China
  • Lin Li
    Pharmaceutical Research Institute and Department of Pharmacology, North Sichuan Medical College, China
  • Zeng Yun
    Pharmaceutical Research Institute and Department of Pharmacology, North Sichuan Medical College, China
  • Zhang Xiang
    Pharmaceutical Research Institute and Department of Pharmacology, North Sichuan Medical College, China
  • Lei Jun
    Pharmaceutical Research Institute and Department of Pharmacology, North Sichuan Medical College, China

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  • Characterization of CTX-M-22 and TEM-141 Encoded by a Single Plasmid from a Clinical Isolate of <i>Enterobacter cloacae</i> in China

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<p>We analyzed the resistance to expanded-spectrum cephalosporins of an Enterobacter cloacae clinical isolate, EC002, by transconjugation, isoelectric-focusing analysis, and cloning experiments. It produced two β-lactamases with isoelectric point values of 5.4 and 8.7, corresponding to TEM-141, a novel variant of TEM-1, and CTX-M-22, encoded by a transferable plasmid.</p>

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