Development and challenges of a noninvasive diagnostic method for oral cancer screening using Saliva

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  • SHIGEYAMA Hiroyo
    Division of Community Oral Health Development, Kyushu Dental University
  • LEE Seung-Woo
    Graduate School of Environmental Engineering, The University of Kitakyushu
  • ANSAI Toshihiro
    Division of Community Oral Health Development, Kyushu Dental University

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Other Title
  • 唾液を用いた口腔がんスクリーニング方法の開発と課題

Abstract

<p>Currently, blood tests, endoscopy, and histopathology are conventionally used to diagnose cancer, but invasiveness and cost are issues. In recent years, noninvasive cancer diagnostic methods that probe the dynamics of the disease by comprehensively analyzing metabolites excreted from the human body have been attracting attention. Volatile organic compounds, in particular, have the potential to become a new disease diagnostic technique because of their high pathological correlation with the body. Still, their application to oral cancer has not yet progressed. In this paper, we report the development of a simple and noninvasive screening method for oral cancer using saliva samples from oral cancer patients, and the validation of its usefulness as a medical tool for biomarker discovery.</p>

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