Drosophila melanogaster as potential alternative animal model for evaluating acute inhalation toxicity

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  • Cho Yoon
    Inhalation Toxicology Research Group, Korea Institute of Toxicology, Republic of Korea
  • Park Chul Min
    Inhalation Toxicology Research Group, Korea Institute of Toxicology, Republic of Korea Division of Practical Research, Honam National Institute of Biological Resources, Republic of Korea
  • Heo Yong-Ju
    Inhalation Toxicology Research Group, Korea Institute of Toxicology, Republic of Korea
  • Park Hae-Bin
    Inhalation Toxicology Research Group, Korea Institute of Toxicology, Republic of Korea
  • Kim Min-Seok
    Inhalation Toxicology Research Group, Korea Institute of Toxicology, Republic of Korea

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  • <i>Drosophila melanogaster</i> as potential alternative animal model for evaluating acute inhalation toxicity

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<p>Drosophila melanogaster (D. melanogaster) is a promising model biological system. It has a short life cycle and can provide a substantial number of specimens suitable for comprehensive genetic and molecular analyses in a short time. In this study, we investigated the acute inhalation toxicity of methylisothiazolinone (MIT) and chloromethylisothiazolinone (CMIT) in a D. melanogaster model. During exposure, environmental conditions, mass median aerodynamic and geometric standard diameters were measured. After inhalation exposure, the survival rate, climbing ability, and bang sensitivity were measured on days 1, 2, and 7. Notably, the survival rate of flies decreased in an exposure concentration-dependent manner. Climbing ability and bang sensitivity were also altered in the MIT/CMIT group, compared with the negative control group. Overall, these results provide a reliable D. melanogaster model system for inhalation toxicity study.</p>

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