Severe consciousness disturbance after cord blood transplantation for relapsed T lymphoblastic lymphoma

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  • NAKAMURA Naokazu
    Department of Hematology/Oncology, Graduate School of Medicine, Kyoto University Department of Hematology, Shinko Hospital
  • MIZUMOTO Chisaki
    Department of Hematology/Oncology, Graduate School of Medicine, Kyoto University
  • SUGIMOTO Akihiko
    Department of Diagnostic Pathology, Kyoto University Hospital Department of Diagnostic Pathology, Shiga Medical Center
  • FUJIMOTO Masakazu
    Department of Diagnostic Pathology, Kyoto University Hospital
  • AYAKI Takashi
    Department of Neurology, Graduate School of Medicine, Kyoto University
  • TAKAORI-KONDO Akifumi
    Department of Hematology/Oncology, Graduate School of Medicine, Kyoto University

Bibliographic Information

Other Title
  • Tリンパ芽球性リンパ腫の臍帯血移植後に見られた高度意識障害
  • Tリンパ芽球性リンパ腫の臍帯血移植後に見られた高度意識障害 : 第119回近畿血液学地方会 優秀演題
  • Tリンパ ガキュウセイ リンパシュ ノ サイタイケツ イショク ゴ ニ ミラレタ コウド イシキ ショウガイ : ダイ119カイ キンキ ケツエキガク チホウカイ ユウシュウ エンダイ

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Abstract

<p>T-lymphoblastic leukemia/lymphoma (T-ALL/LBL) has a poor prognosis. Nelarabine has recently shown relatively good results in patients with relapsed or refractory T-ALL/LBL, but requires careful monitoring for neurological complications. A 50-year-old man with early recurrence of T-LBL after allogenic peripheral blood stem cell transplantation received nelarabine monotherapy and achieved complete remission after 1 cycle. He then received umbilical cord blood transplantation, and experienced sustained disturbance of consciousness. He later died of multiple organ failure, and autopsy suggested that nelarabine-induced leukoencephalopathy had caused the disturbance of consciousness. This case suggests that physicians should carefully monitor patients for neurological complications and consider imaging follow-up and consultation with a neurologist.</p>

Journal

  • Rinsho Ketsueki

    Rinsho Ketsueki 65 (1), 47-51, 2024

    The Japanese Society of Hematology

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