Expression profiles of <i>Tmem120A ⁄ TACAN</i> in rat skeletal muscle subjected to exercise and inflammation

DOI Web Site 参考文献15件
  • Ota Hiroki
    Department of Physical Therapy, Faculty of Rehabilitation, Niigata University of Health and Welfare Institute for Human Movement and Medical Sciences, Niigata University of Health and Welfare
  • Oi Rihito
    Department of Physical Therapy, Faculty of Rehabilitation, Niigata University of Health and Welfare
  • Katanosaka Kimiaki
    Department of Biomedical Sciences, College of Life and Health Sciences, Chubu University
  • Mizumura Kazue
    Department of Physiology, Nihon University School of Dentistry
  • Taguchi Toru
    Department of Physical Therapy, Faculty of Rehabilitation, Niigata University of Health and Welfare Institute for Human Movement and Medical Sciences, Niigata University of Health and Welfare

抄録

<p>Recently, multifunctional roles of Tmem120A ⁄ TACAN in mechanotransduction and mechanical pain hyper­sensitivity have been suggested. Here, we examined the mRNA expression of the molecule in the skeletal muscle and dorsal root ganglia (DRG) using two muscle pain models induced by exercise and myositis. The hind limb muscles of rats were subjected to either lengthening contractions (LC) or carragee­nan injection. The muscles and DRGs were sampled and analyzed using real–time RT–PCR to examine the mRNA expression profiles of Tmem120A. Tmem120A mRNA in muscles increased 6–48 h after LC and 12 h after carrageenan injection. Tmem120B, a paralog of Tmem120A, was upregulated in the muscles of the myositis model, but not in the exercise–induced muscle pain model. Neither Tmem120A nor Tmem120B mRNA level was altered in the DRG of the two muscle pain models. These results indicate that upregulations of Tmem120A ⁄ TACAN and Tmem120B play a role in muscles after inflammation and/or exercise.</p>

収録刊行物

  • PAIN RESEARCH

    PAIN RESEARCH 39 (1), 35-39, 2024-02-07

    一般社団法人 日本疼痛学会

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