Translational research using NAD<sup>+</sup> precursors

DOI
  • Yaku Keisuke
    Department of Molecular and Medical Pharmacology, Faculty of Medicine, University of Toyama
  • Nakagawa Takashi
    Department of Molecular and Medical Pharmacology, Faculty of Medicine, University of Toyama Research Center for Pre-Disease Science, University of Toyama

Bibliographic Information

Other Title
  • NAD<sup>+</sup>前駆体を用いたトランスレーショナルリサーチの現状と将来展望

Abstract

<p>Due to the global increase in population aging, anti-aging research has been vigorously conducted. Nicotinamide adenine dinucleotide (NAD+) is an essential cofactor for maintaining vital cellular functions and has attracted attention as an anti-aging molecule. Demand for NAD+ increases due to irregular lifestyle habits and aging. On the other hand, it is believed that NAD+ supplementation with NAD+ precursors is effective in preventing and treating lifestyle-related diseases and age-related disorders. Among the NAD+ precursors, nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN) have been confirmed to have health-promoting effects in a wide range of animal models. In recent years, clinical trials using NR and NMN have been actively conducted. However, at present, NAD+ precursors in clinical trials have not shown effects as expected from the results of animal models. Meanwhile, basic research targeting NAD+ metabolism itself is being actively continued to achieve more efficient increase in NAD+ levels, and new aspects of NAD+ metabolism are being revealed. Based on these latest findings, we will describe the current status and challenges of NAD+ research and share the path to health promotion through the regulation of NAD+ metabolism.</p>

Journal

Keywords

Details 詳細情報について

  • CRID
    1390862080002412928
  • DOI
    10.32153/ffr.ffr9_p22-27
  • ISSN
    24343048
    24323357
  • Text Lang
    ja
  • Data Source
    • JaLC
  • Abstract License Flag
    Disallowed

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