Long-term follow-up is needed after laser vaporization for cervical intraepithelial neoplasia 3

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  • Yokoyama Takanori
    Department of Gynecologic Oncology National Hospital Organization, Shikoku Cancer Center
  • Hibino Yumi
    Department of Gynecologic Oncology National Hospital Organization, Shikoku Cancer Center
  • Fujimoto Etsuko
    Department of Gynecologic Oncology National Hospital Organization, Shikoku Cancer Center
  • Sakai Mika
    Department of Gynecologic Oncology National Hospital Organization, Shikoku Cancer Center
  • Okame Shinichi
    Department of Gynecologic Oncology National Hospital Organization, Shikoku Cancer Center
  • Teramoto Norihiro
    Department of Pathology National Hospital Organization, Shikoku Cancer Center
  • Takehara Kazuhiro
    Department of Gynecologic Oncology National Hospital Organization, Shikoku Cancer Center

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Other Title
  • CIN3に対するレーザー蒸散術後は長期の経過観察が必要である

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Abstract

<p>Synopsis: Although cervical cancer treatment guidelines recommend conization for cervical intraepithelial neoplasia 3 (CIN3), considering perinatal risks, laser vaporization may be selected. <Objective>To retrospectively examine the treatment outcome and recurrence risk factors of laser vaporization. <Method>In total, 338 patients with CIN3 who underwent laser vaporization during the initial treatment at our hospital from 2014 to 2018 were enrolled. Recurrence rate and risk factors were examined using JMP version 17. <Results>The median patient age was 35 (20-89) years, and median body mass index (BMI) was 20.7 (14.7-34.7) kg/m2. In total, 175 and 153 patients had histories of childbirth and smoking, respectively. Eleven patients (4.7%) exhibited intraoperative blood loss of >50ml. The median follow-up period was 34 (0-83) months. Thirty-two cases recurred, and the 1-, 2-, and 3-year recurrence rates were 2.8%, 6.3%, and 9.1%, respectively. Age, BMI, childbirth history, smoking history, pre-treatment human papilloma virus infection status, and intraoperative bleeding were analyzed for recurrence risk factors; however, no statistically significant differences were observed. <Conclusion>No recurrence risk factors were identified after laser vaporization; however, long-term follow-up is warranted because recurrence rate increases over time.</p>

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