The emergence of evolutionary molecular engineering and its growth in Saitama University

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  • 埼玉大学における進化分子工学の誕生と発展《マイレビュー》
  • 埼玉大学における進化分子工学の誕生と発展
  • サイタマ ダイガク ニ オケル シンカ ブンシ コウガク ノ タンジョウ ト ハッテン

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In modern times, evolutionary molecular engineering is indispensable for bioindustry, especially antibody engineering and enzyme design. The initial study of evolutionary molecular engineering was started and emerged by professor Yuzuru Husimi at Saitama University in the 1980s. I joined Husimi lab for study of origin of life as a graduate student at Saitama University in 1992. Ever since, I have studied evolutionary molecular engineering and the origin of life and developed an artificial virus-type molecule named as “in vitro virus”. In vitro virus is the world's first virus type molecule with genotype-phenotype assignment strategy, that is synthesized with a cell-free translation system. The idea was proposed at Saitama university and accomplished at Mitsubishi Chemical Institute of Lifesciences in 1996. The diversity size of in vitro virus is 10⁵ times larger than that of phage display. Now in vitro virus has been known as mRNA display, and its improved version has been named as cDNA display. In this paper, I review how cDNA display has been developed and how it has been applied.

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