Reproductive and neurobehavioral effects of dinotefuran in a two-generation toxicity study in mice.
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- TANAKA Toyohito
- Division of Toxicology, Department of Pharmaceutical and Environmental Sciences, Tokyo Metropolitan Institute of Public Health
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- SUZUKI Jin
- Division of Toxicology, Department of Pharmaceutical and Environmental Sciences, Tokyo Metropolitan Institute of Public Health
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- INOMATA Akiko
- Department of Pharmaceutical and Environmental Sciences, Tokyo Metropolitan Institute of Public Health
Bibliographic Information
- Other Title
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- ジノテフランのマウスを用いた2世代行動発達毒性試験
Description
<p>Background: Few studies were found on the neurobehavioral toxicity of dinotefuran in mammals. This study was designed to evaluate the reproductive and neurobehavioral effects of dinotefuran in a two-generation toxicity study in mice.</p><p>Methods: Dinotefuran was given in the diet to provide levels of 0% (control), 0.015%, 0.03%, and 0.06% from 5 weeks of age of the F0 generation to 11 weeks of age of the F1 generation in mice. Selected reproductive and neurobehavioral parameters were measured.</p><p>Results: Movement time increased with a significant dose-related trend, and the related variables of rearing time decreased in significant dose-related trends in adult males in the F0 generation. Litter size increased in a significant dose-related trend, and sex ratio decreased in a significant dose-related trend at birth. The average body weight of offspring increased in a significant dose-related trend on a postnatal day (PND) 21 in both sexes. In the olfactory orientation on PND 14 in female offspring, the time required lengthened in a significant dose-related trend. In male offspring, total distance and the average speed decreased in significant dose-related trends, and the average time of rearing, the number of defecations and frequencies of mice with urination increased in a significant dose-related trend. In female offspring, the related variables of rearing increased in significant dose-related trends.</p><p>Conclusions: The dose levels of dinotefuran in the present study produced several adverse effects on reproductive and neurobehavioral parameters in mice.</p>
Journal
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- Annual Meeting of the Japanese Society of Toxicology
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Annual Meeting of the Japanese Society of Toxicology 50.1 (0), P2-194-, 2023
The Japanese Society of Toxicology
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Details 詳細情報について
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- CRID
- 1390862345538126848
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- Text Lang
- ja
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- Data Source
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- JaLC
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- Abstract License Flag
- Disallowed