Effects of Cyclophosphamide on Rat Placental Development
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- FURUKAWA Satoshi
- Nissan Chemical Corporation
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- TSUJI Naho
- Nissan Chemical Corporation
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- HAYASHI Sego
- Nissan Chemical Corporation
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- KIMURA Masayuki
- Nissan Chemical Corporation
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- KOJIMA Chidato
- Nissan Chemical Corporation
Bibliographic Information
- Other Title
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- シクロホスファミドのラット胎盤発生への影響
Abstract
<p>We examined the morphological effects of cyclophosphamide (CPA) on placental development in pregnant rats. CPA was administered as a single dose to pregnant rats intraperitoneally at 0 mg/kg (the control group), 25 mg/kg on gestation day (GD) 12 (the CPA GD 12-treated group), and 25 mg/kg on GD 14 (the CPA GD 14-treated group). The fetal and placental weight decreased in the CPA-treated groups, complete fetal resorption from GD 17 onwards in the CPA GD 12-treated group, and external malformations in the CPA GD 14-treated group. Histopathologically, CPA induced apoptosis and/or cell proliferation inhibition in each part of the placenta. In the labyrinth zone, syncytiotrophoblasts were selectively reduced, resulting in a small placenta. In the basal zone, the number of spongiotrophoblasts was reduced, resulting in hypoplasia of glycogen cell islands. In addition, a small number of interstitial trophoblasts invaded the metrial gland from the basal zone on GD 15. The severity of these lesions was higher in the CPA GD 12-treated group than in the CPA GD 14-treated group. In the metrial gland, although the number of uterine natural killer cells was reduced, metrial gland development was not affected.</p>
Journal
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- Annual Meeting of the Japanese Society of Toxicology
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Annual Meeting of the Japanese Society of Toxicology 50.1 (0), P2-197-, 2023
The Japanese Society of Toxicology
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Details 詳細情報について
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- CRID
- 1390862345538186752
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- Text Lang
- ja
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- Data Source
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- JaLC
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- Abstract License Flag
- Disallowed