Low preoperative hemoglobin A1c level is a predictor of perioperative infectious complications after esophagectomy: A retrospective, single-center study

  • Kato Daiki
    Department of Surgery, National Center for Global Health and Medicine, Tokyo, Japan. Course of advanced and Specialized Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan.
  • Yamada Kazuhiko
    Department of Surgery, National Center for Global Health and Medicine, Tokyo, Japan. Course of advanced and Specialized Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan.
  • Enomoto Naoki
    Department of Surgery, National Center for Global Health and Medicine, Tokyo, Japan.
  • Yagi Syusuke
    Department of Surgery, National Center for Global Health and Medicine, Tokyo, Japan.
  • Koda Hanako
    Department of Surgery, National Center for Global Health and Medicine, Tokyo, Japan.
  • Nohara Kyoko
    Department of Surgery, National Center for Global Health and Medicine, Tokyo, Japan.

抄録

<p>This retrospective, single-center study aimed to evaluate the impact of blood glucose (BG) markers on perioperative complications after esophagectomy in a cohort of 176 patients. Study analyses included the correlation of daily maximum BG level and hemoglobin A1c (HbA1c) with clinicopathological factors. Maximum BG levels were significantly higher on postoperative day (POD) 0 than on PODs 2, 3, 5, and 7 (p < 0.05). Additionally, maximum BG levels on PODs 1, 2, and 7 were significantly higher in patients with preoperative HbA1c levels of ≥ 5.6% than in those with preoperative HbA1c levels of < 5.6% (p < 0.05 for all). The rates of any complications and infectious complications were higher in patients with preoperative HbA1c levels of < 5.6% than in those with preoperative HbA1c levels of ≥ 5.6% (p < 0.05 for both). A preoperative HbA1c level of < 5.6% was a significant predictor of infectious complications after esophagectomy by logistic regression analysis (p < 0.05). Maximum BG level after esophagectomy remained high in patients with high preoperative HbA1c levels, whereas a normal HbA1c level was an independent risk factor for infectious complications. </p>

収録刊行物

  • Global Health & Medicine

    Global Health & Medicine advpub (0), 2024

    国立研究開発法人 国立国際医療研究センター

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