Long-term changes in serum squamous cell carcinoma antigen levels after surgery in patients with sinonasal inverted papilloma

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  • Kitamura Yoshiaki
    Department of Otolaryngology, Institute of Biomedical Sciences, Tokushima University Graduate School
  • Kamimura Seiichiro
    Department of Otolaryngology, Institute of Biomedical Sciences, Tokushima University Graduate School
  • Fujii Tatsuya
    Department of Otolaryngology, Institute of Biomedical Sciences, Tokushima University Graduate School
  • Kanamura Ryo
    Department of Otolaryngology, Institute of Biomedical Sciences, Tokushima University Graduate School
  • Fukuda Junya
    Department of Otolaryngology, Institute of Biomedical Sciences, Tokushima University Graduate School
  • Kondo Eiji
    Department of Otolaryngology, Institute of Biomedical Sciences, Tokushima University Graduate School
  • Azuma Takahiro
    Department of Otolaryngology, Institute of Biomedical Sciences, Tokushima University Graduate School
  • Sato Go
    Department of Otolaryngology, Institute of Biomedical Sciences, Tokushima University Graduate School
  • Takeda Noriaki
    Department of Otolaryngology, Institute of Biomedical Sciences, Tokushima University Graduate School

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Other Title
  • 鼻副鼻腔内反性乳頭腫の術後再発に対する血中 SCC 抗原の長期経過の検討

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This study aimed to examine whether serum SCCA levels can be used as clinical markers for monitoring recurrence of sinonasal inverted papilloma (IP) during the follow-up period after surgery. We measured long-term changes in serum levels of SCCA after surgery in patients with IP and examined whether postoperative SCCA levels were associated with IP recurrence.Twenty-five consecutive patients (13 with primary IPs and 12 with recurrent IPs after their previous surgery) were included in this study. All patients underwent endoscopic or external surgery. Postoperative serum SCCA levels were measured 3 months after surgery and every 3 - 12months during the follow-up. The optimal cut-off values of postoperative SCCA levels to predict subsequent recurrence of IP were evaluated using ROC analysis.Preoperative serum levels of SCCA were higher than the upper limit of normal range in most patients with both primary and recurrent IP, and significantly decreased after surgery. Thus, the presence of IP was closely associated with elevated serum SCCA levels. Moreover, postoperative elevation of SCCA levels was closely associated with subsequent recurrence of IP. Postoperative SCCA levels in 5 patients with recurrence were significantly higher than those in 20 patients without recurrence. The optimum cut-off value of SCCA levels to predict subsequent recurrence of IP 3 months after surgery was 1.85 ng/ml, with a sensitivity of 100.0 % and a specificity of 90.0 %.These findings suggest that SCCA can be a tumor marker of IP. It is also suggested that postoperative elevation of SCCA levels is a clinical marker for monitoring the recurrence of IP during the follow-up period. A SCCA cut-off value of 1.85 ng/ml postoperatively may predict the subsequent recurrence of IP with high sensitivity and specificity.

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