Revealing Mechanisms of Atherosclerosis and Atherosclerotic Diseases Using Angioscopy

DOI Web Site 24 References
  • Komatsu Sei
    Non-profit Organization Japan Vascular Imaging Research Organization Cardiovascular Center, Osaka Gyoumeikan Hospital
  • Higuchi Yoshiharu
    Non-profit Organization Japan Vascular Imaging Research Organization Cardiovascular Center, Osaka Police Hospital
  • Takahashi Satoru
    Cardiovascular Center, Osaka Gyoumeikan Hospital
  • Yutani Chikao
    Non-profit Organization Japan Vascular Imaging Research Organization Cardiovascular Center, Osaka Gyoumeikan Hospital
  • Kodama Kazuhisa
    Non-profit Organization Japan Vascular Imaging Research Organization Cardiovascular Center, Osaka Gyoumeikan Hospital

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  • 血流維持型汎用血管内視鏡を用いた動脈硬化機序および動脈硬化性疾患の解明

Abstract

<p>We have developed a non-obstructive general angioscopy (NOGA) applied for any vessel size. Frequent spontaneously ruptured aortic plaques in the aorta are implicated in organ dysfunction leading to aging. We demonstrated the progression and rupture of plaques via innate immune response involving cholesterol crystals by in situ NOGA studies. Furthermore, NOGA has advanced the identification of detailed endothelial injuries in acute aortic dissections and their application in treatment. NOGA is valuable for the assessment and new therapies for atherosclerotic disease.</p>

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